The Pancreatic Expression Database (PED) is the main repository for pancreatic-derived -omics data. It brings together the largest collection of multidimensional pancreatic data from the literature including transcriptomic, proteomic, methylomic, microRNA and genomic profiles. Read more...
Available Data The Literature database contains data of gene expression measurements or differential expression and copy number alterations extracted from published transcriptomics, proteomics, methylomics, miRNA, meta-analysis or genomics studies (click here for the full list) of various pancreatic normal, benign, precancerous and malignant tissues, body fluids, cell lines and xenograft models under different treatment conditions. Please see the user guide and examples of use for information on how to perform a wide variety of complex queries on various types of data. Pancreatic Expression Landscape We conducted a comprehensive meta-analysis of pancreatic cancer expression space by integrating data from otherwise disparate studies (see publication in PubMed/PDF). Currently, it is the most comprehensive analysis of pancreatic cancer to date. This study stresses the importance of a global-systems approach to assess and maximise findings from expression profiling of malignant and non-malignant diseases. The results of this meta-analysis study are freely available and can be queried and visualised here. Annotations The External Databases provide annotations from several public resources, such as Ensembl Genes / Variation / Regulation, InterPro and PRIDE, enabling the integration and annotation of heterogeneous pancreatic data.
Researchers now have access to the new data portal developed to conduct transcriptomic, genomic and mutational analyses using publicly available data. This includes data obtained from ArrayExpress, Gene Expression Omnibus (GEO), The Cancer Genome Atlas (TCGA) and the Cancer Cell Line Encyclopedia (CCLE). Exploratory analyses of molecular profiles generated through International Cancer Genome Consortium (ICGC) and Genomics Evidence Neoplasia Information Exchange (GENIE) will be available soon. This data portal is interoperable with the Pancreatic Cancer Research Fund (PCRF) Tissue Bank. It will serve as a repositry for mining projects that have requested tissues from the Tissue Bank and will provide tools for customised queries and interactive analyses of the returned multi-omics data and associated clinical/experimental information. This will ensure that the PCRF Tissue Bank-derived and publicaly available pancreatic cancer data are used to their full potential.
The Data Portal is available here.