About PED

The Pancreatic Expression Database (PED) is the main repository for
pancreatic-derived -omics data. It brings together the largest collection
of multidimensional pancreatic data from the literature including
transcriptomic, proteomic, methylomic, microRNA and genomic profiles.
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Data Summary

Available Data

The Literature database contains data of gene expression measurements
or differential expression and copy number alterations extracted from
published transcriptomics, proteomics, methylomics, miRNA, meta-analysis
or genomics studies (click here for the full list) of various pancreatic normal,
benign, precancerous and malignant tissues, body fluids, cell lines and
xenograft models under different treatment conditions.

Please see the user guide and examples of use for information on how
to perform a wide variety of complex queries on various types of data.


Pancreatic Expression Landscape

We conducted a comprehensive meta-analysis of pancreatic cancer
expression space by integrating data from otherwise disparate studies
(see publication in PubMed/PDF). Currently, it is the most comprehensive
analysis of pancreatic cancer to date. This study stresses the importance
of a global-systems approach to assess and maximise findings from
expression profiling of malignant and non-malignant diseases. The results
of this meta-analysis study are freely available and can be queried and
visualised here.


Annotations

The External Databases provide annotations from several public resources,
such as Ensembl Genes / Variation / Regulation, InterPro and PRIDE,
enabling the integration and annotation of heterogeneous pancreatic data.
    

News

Publications

Dayem Ullah AZ., Cutts RJ., Ghetia M., Gadaleta E., Hahn SA., Crnogorac-Jurcevic T., Lemoine NR., Chelala C. The pancreatic expression database: recent extensions and updates. Nucleic Acids Research (Database Issue), 2014; 42(D1): D944-9 PDF

Cutts RJ., Gadaleta E., Hahn SA., Crnogorac-Jurcevic T., Lemoine NR., Chelala C. The Pancreatic Expression database: 2011 update. Nucleic Acids Research (Database Issue), 2011; 39:D1023-8 PDF

Chelala C., Hahn SA., Whiteman HJ., Barry S., Hariharan D., Radon TP., Lemoine NR., Crnogorac-Jurcevic T. Pancreatic Expression database: a generic model for the organization, integration and mining of complex cancer datasets. BMC Genomics, 2007; 8:439 PDF

Literature database

External databases

Data Portal

  Researchers now have access to the new data portal developed to conduct
  transcriptomic, genomic and mutational analyses using publicly available
  data. This includes data obtained from ArrayExpress, Gene Expression
  Omnibus (GEO), The Cancer Genome Atlas (TCGA) and the Cancer Cell
  Line Encyclopedia (CCLE). Exploratory analyses of molecular profiles
  generated through International Cancer Genome Consortium (ICGC) and
  Genomics Evidence Neoplasia Information Exchange (GENIE) will be
  available soon.

  This data portal is interoperable with the Pancreatic Cancer Research Fund
  (PCRF) Tissue Bank. It will serve as a repositry for mining projects that have
  requested tissues from the Tissue Bank and will provide tools for customised
  queries and interactive analyses of the returned multi-omics data and
  associated clinical/experimental information. This will ensure that the PCRF
  Tissue Bank-derived and publicaly available pancreatic cancer data are
  used to their full potential.


PCRFTB data portal

The Data Portal is available here.